Dapox 30mg Tablet: Uses, Benefits and Side Effects

There are many treatment options for PE such as psychological/behavioral therapy, topical anesthetic agents, phosphodiesterase type 5 (PDE-5) inhibitors, and tramadol hydrochloride. Animal and clinical studies in addition to its pharmacokinetic document dapoxetine’s clinical efficacy and safety for on-demand treatment of PE. Articles involving dapoxetine for the treatment of PE were identified, with priority given to systematic reviews, meta-analyses and integrated analyses, double-blind, randomized, placebo-controlled clinical trials (RCTs), and nonrandomized observational studies.

Clinical studies of dapoxetine

The objective of this communication is to summarize the clinical and physiological evidence regarding the role of the serotonergic pathway and specifically dapoxetine in the treatment of PE. Comparison of fold increases in intravaginal ejaculation latency time (IELT) with meta-analysis data for daily paroxetine, sertraline, fluoxetine, clompipramine Waldinger et al. 2004 and phase III data for on-demand dapoxetine Buvat et al. 2009; Kaufman et al. 2009; McMahon et al. 2010; Pryor et al. 2006. Overall, 6081 men with a mean age of 40.6 years (range 18–82 years) from 32 countries were enrolled with 4232 (69.6%) subjects completing their study (Table 2). This is the largest efficacy and safety database for any agent intended to treat PE. There are multiple definitions of PE American Psychiatric Association, 2000; Hatzimouratidis et al. 2010; Masters and Johnson, 1970; McMahon et al. 2004, 2008; Metz and McCarthy, 2003; Montague et al. 2004; World Health Organization, 1994.

Definition, prevalence and aetiology of premature ejaculation

The Dapox 30mg tablet offers numerous benefits for men dealing with premature ejaculation, from improving sexual satisfaction and relationship quality to enhancing psychological well-being. While it may cause side effects in some users, proper medical guidance and adherence to dosage instructions can help mitigate these risks. In the absence of an approved treatment for PE, conventional SSRIs are widely used. Ejaculation delay usually occurs within 5–10 days of starting the treatment, but it may take two weeks for the full therapeutic effect to manifest; ejaculation delay is usually maintained with long-term use. However, daily use of sertraline may cause unwanted and prolonged side effects,8, 9, 10 such as dizziness, nausea, headache, diarrhea, and fatigue, and, given its off-label nature, the use of sertraline for the treatment of PE is considered risky in China.

• By effectively managing this condition, Dapox helps restore confidence and reduces psychological distress.
• During the screening phase of the study, the men’s mean IELT was 1.37 ± 0.12 minutes and both the men and their partners reported being dissatisfied with their sexual lives (Choi et al 2000).
• However, as these methods require patient/partner commitment and practice to maintain viability, their efficacy decreases over time (45).
• These investigators theorized that the rhythmic external urethral sphincter contractions that occur at the time of ejaculation act as a “suction ejection pump”, sucking the genital fluid into the posterior urethra while being relaxed and expulsing it into the bulbous urethra upon contraction.

Key highlights of Dapoxetine

Due to the nature of PE, a change in IELT is the only disease-orientated outcome that is regularly measured and reported. Other frequently reported outcomes are necessarily patient-reported outcomes, and these are discussed later. Table 2 provides a summary of the identified studies reporting changes in IELT with dapoxetine and the quality of evidence supporting these changes. In the studies listed in Table 2, IELT was measured using a stopwatch held by the partner during episodes of sexual intercourse and averaged over the specified baseline and treatment periods.

Medicines, counseling, sexual techniques, or a combination of therapies can help delay ejaculation and improve the sexual experience. The delay in ejaculation allows for prolonged sexual activity, which can lead to a more fulfilling sexual experience for both partners. Although both dapoxetine and sertraline are SSRIs, dapoxetine therapy was satisfactory for 67.5% of patients with LPE in whom sertraline treatment previously unsatisfactory. The initial suggested dose is 30 mg, taken approximately three hours prior to anticipated sexual activity. However, it is important to note that Priligy should not be taken every day on a continuous basis.

In the study by Abdel-Hamid et al (2001), 31 patients with lifelong PE underwent treatments with clomipramine, sertraline, and paroxetine, the squeeze technique, or sildenafil in a randomized crossover design. Sildenafil was administered as needed 3–5 hours before planned sexual intercourse. The authors reported that sildenafil was superior to all of the SSRIs and the pause-squeeze technique in terms of IELT and sexual satisfaction score. In another study, Chen et al (2001) investigated the efficacy of sildenafil in the treatment of severe PE in 58 men who failed other treatment modalities, such as behavioral therapy, topical lidocaine, tricyclic antidepressants, and SSRIs.

However, as these methods require patient/partner commitment and practice to Jintropin (Somatropin) 10 IU Gene Science Pharmaceuticals buy online maintain viability, their efficacy decreases over time (45). An analysis of pooled phase III data confirms that dapoxetine 30 and 60 mg increased IELT and improved patient-reported outcomes (PROs) of control, ejaculation-related distress, interpersonal distress and sexual satisfaction compared with placebo. The pharmacokinetics of single doses and multiple doses over 6–9 days (30, 60, 100, 140 or 160 mg) of dapoxetine have been evaluated.

Both doses of dapoxetine also producedgreater improvements than placebo in subject and partner reported secondaryoutcomes, including ejaculation-related interpersonal difficulty, personaldistress and satisfaction with sexual intercourse. According to sub- groupanalysis of two trials, response to treatment may be limited among men withmild erectile dysfunction. Dapoxetine phase III study design was limited by the use of DSM-IV-TR criteria and a baseline IELT of less than 2 min on 75% of at least four sexual intercourse attempts and enrolment of men with lifelong and acquired PE.

Behavioral therapy was first advocated by Semans in 1956 with the “squeeze technique” and later popularized in the 1970s by Masters and Johnson. This technique involves withdrawal of the penis during intercourse prior to the moment of ejaculatory inevitability, and the partner is asked to apply a sharp squeeze to the glans to abort ejaculation. These investigators theorized that the rhythmic external urethral sphincter contractions that occur at the time of ejaculation act as a “suction ejection pump”, sucking the genital fluid into the posterior urethra while being relaxed and expulsing it into the bulbous urethra upon contraction. Orgasm is a totally separate event, a sensory experience with considerable subjective variation; it can occur independently of ejaculation and even erection.